I use RL-22/RL-23 for our 270s. 140gr accubonds and Hornady ELDX 145gr both shoot really well. accubonds have accounted for Deer,Elk,and a few coyotes. haven't had any ELDXs in a animal yet though. federal,cci,remington primers have been used.
I agree with using one load for as much as possible...