I could chime in here with my limited insight. Shot a total of 9 elk with the following: Nosler Accubond, Winchester Super X, Remington Core Lokt, Federal Fusion and Barnes TTSX all in 180 gr. bullets from a .300 Win Mag. My honest pick of the litter is the Fusion bullet...they just flat out dump energy into an animal. I have recovered several from elk because I'll keep feeding rounds until they tip over. They expand great and hold fair weight. Arguably, I've killed most of my elk with Barnes bullets and no doubt they work great, punch holes through both sides, etc... but I don't see the same amount of shock and internal hemorrhaging from Barnes as I have with the Fusions. Nothing against a TTSX, they shoot extremely well from my rifle and man can they punch through bone, but cup n' core/bonded bullets can surprise too!