I'll admit to vacillating between the .280 Rem & 7MM Rem Mag as best for everything rifle. While I own a rifle chambered for the latter, we're I accorded a do-over, I'd of bought a Sako .280 Rem & never looked back & nor would never needed another rifle. Regardless, in my opinion, anything firing a .284 caliber projectile would deserve consideration.
Next on my short list is the .270 Win.
I will admit that I don't like the idea of losing consciousness when shooting from a bench. Hand loaded .45/70 Govt rounds convinced me that Middle Ages cartridges and me are not compatible. I don't like being knocked back to feudalism.
Cartridges ain't as important as bullet placement. Destroyed heart & or lungs will work every time. Biology is controlling. Nothing living can remain in that condition sans its heart and or lungs. What destroys them is immaterial. That they are destroyed is.