Well since everybody else put in there two cents, here's mine:
The best caliber is the one you are comfortable with. The one that puts the bullet exactly where you want it!
My comfortable caliber happens to be the 7mm. Rem. mag. The reason I chose this is I believe 300 win or short is way overkill on alot of game that I hunt or plan on hunting. I wouldn't want to kill and antelope with one. I want to eat it when I'm through. I would not be emberassed or underpowered shooting a moose with my weapon because I am going to put a well placed bullet where I want to or I'm not going to pull the trigger. I think these big calibers are a compensating mechanism for lack of practice with their equipment. If I was just hunting mule deer and antelope, I would go with 6mm rem. or possibly 25-06. I hope I dont offend anybody and that is not near my intention, but that is my opinion. Also bullets have a better bc with a 7mm
Like the 300, I believe the 7mm offers the same amount versatility as far as bullet weight goes, or should I say a bullet for any animal. What I mean is you can choose a bullet to hunt antelope and to hunt moose.
My uncle owns a 300 wsm and his load is like 95 gr.powder!!! Holy Mackel Andy! That's alot of powder!!!