I shoot a 30-06 with 165 grain Hornady Interbonds. I have taken 20+ elk with this setup. As a hunter and guide, I have seen a gob of different calibers kill elk and I'm not sure there is a perfect, one size fits all for everyone. Recoil, shooting distances, and ability are all things to be considered. I personally don't shoot high recoil guns very well so I stick with my 30-06. Better to have a non-magmum in the boiler room than a marginal shot from a magnum.