I used to antelope hunt with my .280 and it was a fine cartridge. Then I started using a .300 Win Mag and thought that was a great cartridge, especially when shooting across the windy plains. A couple of years ago, I got a .25-06 and I absolutely think it's the ideal antelope cartridge. High velocity with mild recoil. I deer hunted with it this fall in Missouri and noticed the recoil is light enough that I can watch shot impacts through the scope. That's nice. Accubonds wouldn't group in my .25-06, but 115 gr Ballistic Tips group well and have performed well on antelope and whitetails.