I have a Rem 700 22-250, a standard 243, and an A-bolt 243wssm. I had rather carry the short action 243wssm, but I like the 22-250 cal best. Its amazing what the 22-250 will do. The BOSS on the Browing lets you change ammo quickly and not lose accuracy, like 55gr or 95 gr.
I try not to reload either, the ammo you can buy will be very accurate once you match the weight and twist rate your gun likes. A guy I know bought a Howa 223 package for not too much money and he likes it really well. My brother also has a 223 gun with a fast twist and he can shoot a deer weight bullet with it. Last year, my friend killed a 322lb bear with a 223 and I killed a bear with the 243wssm. Same gun, I shot a large whitetail buck with a 55gr bullet, a pass through clean kill. Confused yet?