I have a 10mm Glock (A G20). I really enjoy it as a handgun but I find myself carrying it less and less. It's honestly just the weight and size.
In upland game / turkey / waterfowl seasons when I have a shotgun I never carry it - I just bring a few slugs. During rifle season I have that, and despite the stories, bear/cougar attacks during a field dressing operations (when I'd set it down) are VERY rare, at least here in Colorado. And I'm no archer but I'd bet the CPW would give the hairy eyeball to anybody carrying a big pistol on an archery hunt "just for self protection". And it's kind of a ridiculous thing to have on you "in camp", like you're expecting a German invasion or something!
Another issue for me is where to carry it. I don't like drop-leg holsters - at least, with the two I've tried, it flops around too much when you're squeezing through brush. It's too big for an ankle holster, and appendix/back carry with bulky hunting clothes doesn't leave it readily accessible, and interferes with prone-shooting/glassing and wearing a pack. Hip carry interferes with shoulder-carry of a shotgun/rifle (I've tried every angle/position, and have the scuff marks on the sides of things to show my failures). Chest carry works REALLY well with it - unless you want a bino harness. Which I do. So...
And the G20 with a single 15-rd mag weighs 2lbs 14oz. There are tents that weigh less than that! My average hike is 5-10 mi. I definitely notice the difference at the end of a day.
Finally, even when I work around all this, when I get done with my day and get in the truck I still can't carry it anywhere - hip carry would be my preference (I love my Blackhawk Serpa holster with it) but it interferes with the seatbelt or digs into my hip. Chest carry is ridiculous while driving down the highway. And it's really too big to conceal comfortably, at least for me. So I take it off... in which case what good is it doing me?
At the end of the day, while hunting, I always fall back to "my main weapon plus a can of bear spray". For camp or driving, a G42 380 that I never take off.
That said:
1. It makes a VERY nice sidearm while scouting or generally hiking, especially on the chest rig I have. When I'm not carrying a long-arm, I always have this.
2. I'd be lying if I didn't admit I still love pistols. I've been toying with getting a scoped pistol with a 10" barrel. I hunt for meat, not trophies, and 7 in 10 times (if not more) I run into game, it's bumping a doe while poking around a small meadow on an early-season scouting hike for a later-season hunt. If I had a pistol I was confident out to 30-40 yards or so with, something like a BFR or Taurus Hunter in 444 or 45 Mag, I honestly might just carry that and leave the 8lb rifle in the truck. I know it sounds silly, but pistols are fun!