Yeah, there are some really good factory loads for the 270, and even the standard "cheap" loads from the big companies are really effective on deer. At real long range in heavy wind (which being from KS you know all about) the higher BC bullets start to really take over.
I find running the ballistics program and shooting in real life that I'm better off deciding how far I want to be able to shoot and weighing that against how fast I need to be able to shoot. Until you get to extreme range the short time of flight a high velocity gives you often beats the efficiency of a slower, higher BC bullet.
For example for coyotes I use a 70gr ballistic tip from a 6mm at 3824fps with the Hodgdon Superformance powder. It lets me hold dead center out to 350yds and stay within the vitals, no guessing at hold-over, no dialing, just shoot. Past that the low BC has the velocity dropping off, wind drift increasing, and it's easier to make hits with some of my other rifles. Coyotes often feel safe enough to stop and look back for a second somewhere in the 250-350yd range where other hunters might pass on a shot. If I'm ready to shoot the instant they stop to look back I get a lot of dogs others don't. For an antelope or deer hunt I'm hopefully shooting prone or from a bipod at a animal with no idea I'm there, plenty of time to range it and use the wind meter and wind chart, dial the 264 correctly and send a 140gr Berger right where I want it. I can shoot farther with greater precision, but it takes more time to set-up properly for the shot.
Hopefully some of this will help the OP, really think about what you want the rifle to excel at and plan it accordingly.