I don't want to take shots much past 250, and why my rifles are all zeroed at that range. I never set out with the intent of twisting a turret, but have no problem doing it when necessary.
But, I'm also honest with myself. I've applied for tags for multiple species in multiple states for the last 2 decades...some over 3 decades.
Good tags roll around less and less often all the time, so I asked myself what would happen, if on the last day of a hunt I was afforded a shot at a once-in-a-lifetime animal at 4-5 hundred? I would take that shot no matter if it was by holdover or by turret. Next question I asked myself, what's the best way to achieve the result of an ethical, one shot kill in that situation? IME, that would be via twisting turrets over having to "guess" hold over.
I've done a lot of both, and I see no "advantage" of holdover...and a whole lot more disadvantages. Simply put, if holding a foot or two over the back of an animal was the best way to do things, I would...but its just not.
To each their own...just make sure you're not shooting beyond your limits or the limits of your equipment.