There are lots of custom and semi-custom gun makers, and most claim they are best at what they do. Some make 20 pound varmint rifles, while others focus on 5 pound mountain rifles, and other yet believe in fancy engraving and extravagant wood.
You really need to define some parameters. To this open ended question I might choose a Holland and Holland double rifle for about $150K+, but I won't plan to take it sheep hunting anytime soon.
Kimber makes quality production rifles at a cost far less than Dakota. Nothing wrong with Dakota, but the great wood and finish doesn't make them kill better, or any more accurate. Most brands produce rifles capable of accuracy less than 1", but many hunters can't perform this well themselves repeatedly.
Decide what purpose you envision for the gun, whether it is investment, target practice, or specific type of hunting. Plan your purpose with the goal in mind, and don't get hung up in endless debates about best.
llp