I have always had a 280 AI since I started hunting the west, back in the late 80s i formed my own brass like everyone else did. This is to say the loads were not available over the counter. The 160 Partition was what I started with and as ususal looked around for a better bullet. I had a few performance failures with the old 162 gr Nosler solid base, they fell apart, shattered or just didnt penetrate very well.
This year I went back to the 160 gr partition for elk and got a bang-flop at 25 yards. End of story.

As a side note my hunting buddy went looking for 280 rem ammo in Jackson WY, we did not find any ...lots of 280 AI ! How times have changed !