If you look at the unit maps in the regulations, there is crosshatching in all of the designated wilderness. That is where a guide is required.
The largest majority is in the areas near Yellowstone, with some in the Bighorn Mountains (north central Wyoming) and a bit in the SE part of the state, I believe that is the Snowy range.
There is an immense amount of public land in Wyoming where no guide is required and you can have a great DIY hunt.
We'd love to learn more about you and have you stick around the forum and share your hunting experiences. Would you consider starting a thread and introducing yourself?