There are several things to consider. First are there many houses around? Second..what ranges are you going to shoot. Using 22LR sounds to me like its 100 yds or less. One bad thing about 22LR is the rick-o-shay (using my favorite cartoon characters name!) factor which is large with the LR. It can be dangerous especially with houses around.
I use a .17HMR that is just deadly up to 150 yards. Its quiet and safe as the bullet just explodes when it hits anything. At longer ranges I use a .220 Ackley Improved Swift. If I had just one to choose from it would be the .17 ....hand down. Fairly cheap and very accurate.