I always use liners and always carry an extra pair of liners and regular socks for trading out should my feet get too sweaty. You also have to keep your foot from moving in the boot. Just filling it with sock doesn't usually work for very long.
Another thing is that I change my socks regularly and air them out when I get a chance - another nice thing about the Thorlos, they dry quickly.
Cold weather, I wear the Thorlos and put a pair of wool socks over top of them.
For boots, make sure that they are not too big - if your feet are sliding around in your boots, you're going to get blisters no matter what you wear.
Personally, I wear Merrells at home and I'm still working on finding a good pair of hunting boots. The soles on the Merrells are too soft for going off-trail too long, otherwise, I'd wear those hunting, too.
Another thing, get out and walk more at home, it will thicken the skin and build some callouses on your feet.
And like Kevin Root said, take good care of your feets, keep them clean and dry.
Ah, the nostalgic aroma of a yak dung stove brewing up some tea full of herbs best left untranslated.
From the Zen Backpacking Site
I've use sock liners sometimes. I also wear thorlos. Love them. I wear them everyday. I did pick up some merino blend socks of steep and cheap, so far so good, a little less cushion than the thorlos however but they haven't passed the test of time.
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Thanks for all the info. I'll have to check into the smart wool and darn tough socks. Has anyone tried cabelas ingenious socks? I got a couple pairs for Christmas but I've only worn them deer hunting and pheasant hunting. I put some miles on them but it was all pretty much flat walking. Not much for hills in northern Ohio or Minnesota, at least where I hunt.