Wasn't there once a good article/study where they killed off a bunch of buffalo on a private ranch testing the effects of various sized rifles on buffalo. I remember reading where the size of the bullet had little to nothing to do with a DRT shot but it had to do with one of 2 things. They had several rifles and several buffalo to use. THey found that the likely hood of dropping an animal in its tracks was the same across the spectrum of weapons regardless. Basically it required the CNS disrubtion or the other thing I found really interesting is the autopsy showed a significantly higher rate of DRT shot when they animals had just exhalled and the pause between hear beats. I remember it from a while back.
For me shot placement depends on the situation. If I need an animal to drop now then high front shoulders are used (for example my wifes bull was only 80 yards from private this year in 2 directions and 15 yards from a nasty cut wash. So she shot a high front shoulder. That same situation with no wash or private would have went for a typical heart lung shot.
At anyrate, watch the shows and while they show several animals DRT, there are many they look for and also realize that most of those animals are smaller bodied white tails and way more of them.