I have (or have had) guns in pretty much all of the calibers mentioned. I absolutely LOVE the 7mm-08! It is a great cartridge. I have .270's and really like them as well. 25-06 is a cartridge you really can't argue with at all, and I am really attached to my Weatherby
(Southgate made) in .257, it shoots great (so does the .240 I have, it is a one hole gun at 100 yards). All that aside, my son's (now my wifes, since the 14 yeaar old son 'Borrowed' one of my .270's and claims it as his own) .243 is without a doubt the best shooting, "can't figure out why it stomps deer into the ground", deer rifle in the gun safe. I have heard all the "it isn't as good as xyz caliber on paper" talk and all I can say is there is something about that caliber that really is a PERFECT marriage between bullet weight/available premium bullets/BC and everything else I can think of. I've watched my son shoot a lot of pretty nice white tails and flat drop them in their tracks with a .243 shooting Federal premium 100 grain Sierra Game Kings (A bullet that some people are very critical of, but those that shoot them seem to love). For the light recoil, available selection of premium factory ammo or reloading components, great rifles by multiple makers, it is hard to beat.... then again, all that same stuff is true of a .25-06. I'd say close your eyes, flip a coin and go with the toss!